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Promethazine with Codeine Uses, Side Effects & Warnings - Drugs.com Promethazine with Codeine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Promethazine with Codeine may also be used for purposes not listed in this medication guide. Warnings

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