Is it okay to take an expired pepto bismol (bismuth subsalicylate)? Can I take pepto bismol (bismuth subsalicylate) that expired in April 1 doctor answer • 1 doctor weighed in Dr. Richard Bensinger answered Ophthalmology 54 years experience Yes: It will still have the same effect as long as the bottle had not previously been opened. Created for people with ongoing healthcare needs but benefits everyone.